Synthesis and evaluation of vitamin D receptor-mediated activities of cholesterol and vitamin D metabolites
نویسندگان
چکیده
منابع مشابه
A Prospective Study of Plasma Vitamin D Metabolites, Vitamin D Receptor Polymorphisms, and Prostate Cancer
BACKGROUND Vitamin D insufficiency is a common public health problem nationwide. Circulating 25-hydroxyvitamin D3 (25[OH]D), the most commonly used index of vitamin D status, is converted to the active hormone 1,25 dihydroxyvitamin D3 (1,25[OH]2D), which, operating through the vitamin D receptor (VDR), inhibits in vitro cell proliferation, induces differentiation and apoptosis, and may protect ...
متن کاملEvaluation of relationship between BMI with vitamin D receptor gene expression and vitamin D levels of follicular fluid in overweight patients with polycystic ovary syndrome
Background Polycystic ovary syndrome (PCOS) is the most common endocrine disorder. The roles of vitamin D in the regulation of metabolic modulations specifically involving insulin action and reproduction processing are introduced. In addition, obesity appears to be closely associated with severity of PCOS. The aim of this study was to evaluate the effect of BMI on vitamin D levels in follicular...
متن کاملCirculating vitamin D metabolites, polymorphism in vitamin D receptor, and colorectal adenoma risk.
OBJECTIVE Vitamin D is a potential agent for the prevention of colorectal cancer possibly through mechanisms mediated by the vitamin D receptor (VDR). We investigated the association of circulating vitamin D metabolites and a genetic variant of the VDR gene with advanced colorectal adenoma, a precursor lesion of colorectal cancer. METHODS Cases with advanced adenoma of the distal large bowel ...
متن کاملDetermination of vitamin D and its metabolites.
The demand for analysis of 25-hydroxyvitamin D has increased dramatically throughout the world over the past decade. As a consequence, a number of new automated assays have been introduced for 25-hydroxyvitamin D measurement. Automated assays have shown variable ability to meet the technical challenges associated with 25-hydroxyvitamin D measurement. Assays are able to meet performance goals fo...
متن کاملVitamin D, vitamin D receptor and tissue barriers
Tissue barriers are critical in the pathogenesis of human diseases, such as atopic dermatitis, inflammatory bowel diseases, and various cancers. Preserving or restoring barrier functions of the epithelia cells is a therapeutic strategy to prevent and treat the illness. Mounting evidence indicates that vitamin D and the vitamin D receptor (VDR) play key roles in the pathogenesis of human disease...
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ژورنال
عنوان ژورنال: European Journal of Medicinal Chemistry
سال: 2016
ISSN: 0223-5234
DOI: 10.1016/j.ejmech.2016.01.002